The field of genetics that started with Mendel's idea of gene and allele has propagated through the advent of molecular biology. And currently, the field has even moved further through the understanding of genome architecture and epigenetic regulation that drives biological processes. Chromatin landscape and non-coding RNAs can play important role in development and sex-chromosome dosage compensation, diseases including neurodegenerative disorders as well as cancer. Overall, 3D genome organization encompasses genome organization in 3D nucleus space, DNA topological aspects, chromosome territories etc.  3D genome organization has been attributed to allele-specific mRNA expression patterns like genomic imprinting and random monoallelic gene expression which regulate development and disease phenotypes. Thus, understanding overall spatiotemporal regulation of chromatin landscape and RNA biology is critical to gain insights to the overall adaptive fitness of any organism. It is not a single gene or just a set of genes that can drive biological processes in cellular and organismal level, but the overall genome architecture and transcriptome is important. This two-day conference will facilitate an exchange on the understandings in the field so far. Also, highlights might come up regarding how can the field proceed in future to better understand chromatin biology and its implications.